In Tsarist Russia, a doctor in a provincial hospital encounters a former student in the mental ward and he harbors a fascination with his rebellious patient. The doctor believes that he is intellectually superior to everyone except for this political prisoner. Listening to his patient, the doctor develops a new view of reality, much to the displeasure of his colleagues. Ward 6 is a metaphor on life under repressive governments, conformity versus individual expression.
Five inmates in a medical ward, with no memories of their past, try to figure out who they are and where they came from. When one of them, who they believed to be dead, returns looking healthier then ever, they realize they are merely puppets in a strange experiment. Their only hope, escape.