The Logic of Chemical Synthesis by E. J. Corey
Publisher: Wiley-Interscience; 1 edition (June 29, 1995) | ISBN: 0471115940 | Pages: 436 | PDF | 5.96 MB
The Logic of Chemical Synthesis The title of this three-part volume derives from a key theme of the book—the logic underlying the rational analysis of complex synthetic problems. Although the book deals almost exclusively with molecules of biological origin, which are ideal for developing the fundamental ideas of multistep synthetic design because of their architectural complexity and variety, the approach taken is fully applicable to other types of carbon-based structures. Part One outlines the basic concepts of retrosynthetic analysis and the general strategies for generating possible synthetic pathways by logical reduction of molecular complexity. Systematic retrosynthetic analysis and the concurrent use of multiple independent strategies to guide problem solving greatly simplify the task of devising a new synthesis.